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Physiological Model Solutions

Enhance the relevance of your research

Drug discovery endeavors require a deep understanding of biological systems and their response to potential therapeutics. That’s where microphysiological systems (MPS) play a pivotal role. They offer a more accurate representation of cellular biology that goes beyond traditional approaches, enabling researchers to understand disease mechanisms and find new treatments that translate into clinical response.

If you are working on your next 3D cell project, and trying to select the right culture method, genetically modify your cells, automate your workflow, or analyze your samples and data, at Revvity we have the technologies and solutions to partner with you with the purpose of reaching your goals. Together, we can redefine what’s possible by developing innovative treatments and precise therapeutic solutions to improve human health and lives around the world.

Animal modelsStem cell and iPSC-derived disease modelsOrgan-on-chipBioprinted modelsSpheroids and organoids
Physiological model solutions benefits interactive imageThis SVG depicts various shapes and models related to spheroids and organoids in biological studies, including representations of animal models and stem cell-derived disease models.Animal modelsStem cell and iPSC-derived disease modelsOrgan-on-chipBioprinted modelsSpheroids and organoids


For research use only. Not for use in diagnostic procedures.

Physiological Model Solutions
Culture

When it comes to developing advanced physiological models — it’s critical to select the cell model with the right genomic context and biological function to recapitulate a healthy or diseased phenotype.

Achieving this level of accuracy requires tightly controlled culture conditions and reliable cell counting for cell seeding. Choosing a 2D or 3D culture method depends on the biological question, complexity of the desired model, and readout technology. Cells can be grown as monolayers, single spheroids in ultra-low attachment (ULA) plates, or cultured in hydrogels, offering a variety of options to enhance your research capabilities. Count on us to expertly scale up these methods, utilizing liquid handling techniques.

Featured products:
growdex hydrogels
GrowDex Hydrogels
We offer a range of products for scalable animal-free 3D cell culture applications, providing convenience and consistent results.
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Microplates
Choosing the right microplate is a critical, often overlooked, part of an assay. The right microplate helps provides valuable data, whereas the wrong microplate can lead to missed or inaccurate data leading to missed project timelines and ultimately higher costs.
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Fontus Liquid Handling Workstation-Revvity-512x288
Fontus Workstations
With easy-to-use software, optimized deck access, verified protocols, and reformatting capabilities to simplify your workflows and improve turnaround times
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Cell Counting & Image Cytometry Instruments
Revvity offers a leading portfolio of automated cell counters, image cytometry systems, and cell counting reagents and consumables. Together, they provide fast, accurate and efficient ways to assess cell health and viability, immunophenotyping, and perform a range of other routine cell-based assays.
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Viral Vector Products
Viral vectors are the most efficient vehicles for gene delivery into a specific cell type or tissue for a wide array of research purposes.
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Recombinant Proteins
Our portfolio includes over 2,000 bioactive human, mouse, and rat recombinant proteins developed in-house.
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crispr technologies
CRISPR Technologies
CRISPR-Cas9 genome engineering technologies hold great promise for understanding diseases and for the development of life saving treatments.
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Treatment

In modern drug discovery, multiple screening methods play a vital role in identifying potential drug targets and eventual drug candidates. Traditionally, small molecule libraries were screened for compounds acting on a known molecule or for a desired biological effect. However, a drug candidate is only as good as its target.

To ensure the utmost precision, today’s drug discovery leverages gene editing or gene silencing methods such as CRISPR or siRNAs to identify suitable drug targets. Understanding the causal gene behind a phenotype or genes that contribute to a phenotype can significantly boost the confidence in a new drug candidate. Get ready to experience advancements in your research as we deliver convenience and efficiency.

Featured products:
Fontus Liquid Handling Workstation-Revvity-512x288
Fontus Workstations
With easy-to-use software, optimized deck access, verified protocols, and reformatting capabilities to simplify your workflows and improve turnaround times
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crispr technologies
CRISPR Technologies
CRISPR-Cas9 genome engineering technologies hold great promise for understanding diseases and for the development of life saving treatments.
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rna interference
RNA Interference
Dharmacon™ siRNA, shRNA, and microRNA-based reagents, leading the field for for nearly 30 years providing highly specific and efficient gene silencing.
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Model Analysis

Selecting the right method for measuring the biological response of 3D models depends on the specific research question and the characteristics of the model system in use.

Whether you’re repeatedly monitoring microtissue size or measuring sensitive detection of secreted proteins, each readout type poses unique challenges that can be overcome with the right tools. Our microplate readers, high-content analysis systems, and innovative reagents are complemented by specially designed microplates. Together, they shine a light on your samples, offering powerful insights to propel your research forward.

Featured products:
LabChip GX Touch Nucleic Acid Analyzer
LabChip GX Touch Nucleic Acid Analyzer
Accurate sizing, quantification and quality control of DNA, RNA, and NGS libraries. The LabChip® GX Touch™ nucleic acid analyzer is a comprehensive solution for genomic sizing and quantitation. It offers: <ul> <li>Quantitation of DNA and RNA sample integrity hours faster than agarose gels</li> <li>Maximize rare or low-concentration samples like cfDNA, PCR-free libraries, and ChIP-seq libraries</li> <li>Accurate quantitation down to 25 pg/µL for DNA smears and 0.5 pg/µL for fragments</li> <li>NGS library prep analysis and QC</li> <li>Flexible throughput options making it a cost-efficient – 96-well or 384-well (HT) format</li> <li>Data visualization options (electropherogram, virtual gel, or tabular report)</li> </ul> The LabChip GX Touch nucleic acid analyzer also supports a variety of DNA and RNA analysis, which provides unparallel genomic data quality with minimal input requirements. When the concentrations are low, and samples are precious, The LabChip® DNA High Sens and RNA Pico assays are ideal choice for reliable measurement and sample preservation. With complete analysis of genomic material in about 30 seconds, the LabChip GX Touch nucleic acid analyzer eliminates the nucleic acid quantitation workflow bottleneck. High-resolution analysis provides exact sizing and quantitation of DNA fragments and smears down to 5 bp from samples as small as 2 pg/µL. The system offers a broad variety of DNA analysis options, including the NGS 3K assay, which provides unparalleled genomic data quality with minimal input requirements. This high degree of sensitivity also makes it the ideal instrument for gDNA and PCR-free DNA quantitation, where concentrations are low, samples are precious, and their preservation is essential. Purity and integrity analysis of mRNA-based vaccines By using LabChip® RNA Assay, researchers at Merck developed an assay to characterize purity and integrity of mRNA vaccines. This fast, easy and efficient workflow helped speed up vaccine development and meet increased manufacturing high volume demand. The system offers a broad variety of DNA analysis options, including the NGS 3K assay and the cfDNA assay, which provide unparalleled genomic data quality with minimal input requirements. This high degree of sensitivity also makes it the ideal instrument for gDNA, cfDNA, and PCR-free DNA quantitation, where concentrations are low, samples are precious, and their preservation is essential. Dimensions <ul> <li>Height 69 cm | 27 in</li> <li>Width 51 cm | 20 in</li> <li>Depth 49 cm | 19.5 in</li> </ul>
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3D Cell Model Imaging and Analysis
3D cell culture models, such as spheroids, organoids, and microtissues, have gained popularity as tools for research, drug discovery and toxicity studies.
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microplate readers
Microplate Readers
As many of you know, microplate readers are instruments used to detect biological, chemical, biochemical or physical events from samples in a microplate.
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immunoassays
Immunoassays
Since their introduction in the 1950’s, immunoassays have been an integral part of research and drug discovery.&nbsp;
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Luminescence Assays
Luciferase assays allow for the study of transcriptional gene expression, virus life cycles, and cell viability.
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nucleic acid isolation
Nucleic Acid Isolation
Revvity provides a unique and efficient method for isolating nucleic acids based on chemagic™ technology established over 25 years.
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Cell Counting & Image Cytometry Instruments
Revvity offers a leading portfolio of automated cell counters, image cytometry systems, and cell counting reagents and consumables. Together, they provide fast, accurate and efficient ways to assess cell health and viability, immunophenotyping, and perform a range of other routine cell-based assays.
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Multiomics and TotalSeq Reagents by BioLegend
Multiomics provides unparalleled protein and genetic analysis. Explore how our TotalSeq™ reagents can be integrated into your existing workflows and expand your capabilities.
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Data Analysis

Extracting insights from complex 3D datasets is no easy task. It requires the meticulous analysis of readouts and vast amounts of information (in context). But no worries—we’ve got you covered.

With our scientific software and informatics solutions, you gain the ultimate tools to optimize 3D cell model imaging. Seamlessly aggregate, search, mine, and visualize critical data, converting it into actionable insights that drive your research forward. We are here to help you meet the challenges of data analysis head on—so you can embark on a journey of ground-breaking discoveries.

Featured products:
Signals Image Artist

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signals Research Suite
Signals Research Suite
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