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Biologics immunogenicity and PK/PD
The immunogenic potential of biotherapeutic drug molecules can have an effect at any point, from its administration through to metabolism and elimination. Therefore, it is important to understand the impact of immunogenicity upon the PK and PD properties of a large molecule drug.
The characterization of the effect of anti-drug antibodies on the PK is critical. The development of a physiologically relevant PK model in the context of the immunogenicity profile offers significant value to preclinical development.
We offer technology platforms that enable in vitro, ex vivo, and in vivo evaluations to help you understand the immunogenicity of your biologics.
Automated Liquid Handling
Microfluidic Nucleic Acid Analysis
In Vivo Imaging Instruments
High Content Screening Instruments
Cellular Imaging Software
Immunoassays
In vitro assay
Leverage reliable in vitro assays to help better understand the interactions of the innate and adaptive immune response for your discovery and development of immunotherapies
We offer a range of assays for characterizing cytokine response, screening biologics, measuring signalling events, determining mechanism of action, and understanding the antibody-dependent cellular cytotoxicity (ADCC) of the biologic.
Luminescence Assays
Radiometric Detectors
Radionuclides
Immune Cell Screening
Immunoassays
