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Application Note

Dry milling of analgesics for particle size reduction on the Omni Bead Ruptor 96

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Milling is a crucial process in pharmaceutical production and process control, used to enhance solubility and stability of drug compounds through particle size reduction. We explored optimizing dry milling parameters to achieve effective particle size distributions, as dry milling is typically preferred for maintaining product integrity and scalability. On the Omni bead mill homogenizer, optimal milling frequency for analgesics ranged from 25 Hz and 30 Hz, with the most significant particle size reduction occurring within the first minute of milling. Extended milling times beyond five minutes showed negligible additional reduction.

For research use only. Not for use in diagnostic procedures.

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Dry milling of analgesics for particle size reduction on the Omni Bead Ruptor 96

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