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Literature - Publication Review
Countering vascular calcification through mitochondrial phosphate transport inhibition in a CKD murine model
Hyperphosphatemia is a complication of reduced kidney function in individuals with chronic kidney disease (CKD) and is associated with cardiovascular tissue calcification, which can lead to cardiovascular morbidity and mortality. Given the significant biological consequences of hyperphosphatemia in CKD, researchers investigated the role of mitochondrial phosphate transport in vascular calcification.
Learn how, through targeted genetic suppression of PiC and pharmacological inhibition of mitochondrial phosphate uptake, researchers were able to uncover a pivotal role of PiC in this process and demonstrate the potential efficacy of pharmacological inhibitors in reducing vascular calcification.
For research use only. Not for use in diagnostic procedures.
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Countering vascular calcification through mitochondrial phosphate transport inhibition in a CKD murine model