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Moving hits into high-quality lead series is the main goal of hit to lead optimization in drug discovery. During lead optimization, analogs of leads are prepared and synthesized to improve biological properties for clinical development. The aim is to improve target selectivity and biological activity, and reduce potential toxicity.
With our validated screening assays and multimode plate readers, state-of-the-art instruments for high content and in vivo imaging, integrated automation for liquid handling, and powerful analysis software, our portfolio brings consistent, accurate, physiologically relevant results for faster discoveries and impactful breakthroughs so you can gain more confidence in your discovery.
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