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Whitepaper Icon   Whitepaper
The role of in vivo imaging in drug discovery and development
Preclinical in vivo imaging helps to ensure that smart choices are made by providing go/no-go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.
Publication Icon   Literature - Publication Review
Evaluating a novel nanoparticle platform for controlled liraglutide release in a Type II diabetes mouse model
Optical imaging using the IVIS® Platform to evaluate a novel nanoparticle system for controlled liraglutide release in a diabetic mouse model.
Case Study Icon   Case Study
Using IVIS optical imaging of CRISPR/Cas9 engineered adipose tissue to study obesity prevention
Assessment of brown fat activation of CRISPR engineered adipose tissue in a mouse model using Revvity's IVIS® optical imaging platform.
Case Study Icon   Case Study
Temporal tracking of an effective intervention in rodent liver fibrosis
Visualize, track, and quantify progression & regression of liver fibrosis using the Vega® non-invasive 3D ultrasound system.
Case Study Icon   Case Study
Automated ultrasound for non-invasive in vivo evaluation of liver disease progression in mice
Case study evaluated automated ultrasound for non-invasive in vivo evaluation of liver disease progression in mice.
Publication Icon   Literature - Publication Review
Ultrasound imaging provides noninvasive 3D views into vascular changes in response to cancer therapy
Ultrasound imaging using the Vega® automated system provides noninvasive 3D views into vascular changes in response to cancer therapy.
Publication Icon   Literature - Publication Review
Improving engineered T cell efficacy for treating solid tumors through epigenetic modulation
Researchers used the Opera Phenix® HCS and IVIS® preclicinal imaging system to evaluate engineered T-cells through epigenetic modulation showing the potential of improving the cytotoxic effects on solid tumors.
Publication Icon   Literature - Publication Review
Exploring mechanisms behind alphavirus-induced post-encephalitic parkinsonism
neuroinvasive viruses eliciting neurodegenerative symptoms of post-encephalitic parkinsonism by using bioluminescent or fluorescent recombinant WEEV in an in vivo mouse model
Publication Icon   Literature - Publication Review
Utility of engineered human Neural Stem Cells (NSCs) expressing varying exon 1 HTT fragments to study Huntington’s disease
Huntington's disease is most commonly caused by an expansion mutation in the CAG trinucleotide repeat within exon 1 of the HTT gene which codes for the protein huntingtin.
Publication Icon   Literature - Publication Review
A lung tropic AAV vector improves survival in a mouse model of surfactant B deficiency
Researchers design an adeno-associated virus (AAV) 6 capsid that demonstrates efficiency in lung epithelial cell transduction in a mouse model validated using optical imaging.
Whitepaper Icon   Whitepaper
Establishing an automated high-throughput assay that supports the growth of prostate cancer organoids
Researchers concluded that their study demonstrates the ability to automate preclinical testing with prostate cancer organoids with diverse phenotypes.
Publication Icon   Literature - Publication Review
Next-generation antimalarials: new hope on the horizon
In this literature review, we explore the emerging challenge of antimalarial drug resistance and the need to analyze all stages of the malaria parasite lifecycle to help develop the next generation of therapeutics.
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